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Reply To: Clinical Trials

GCS Project Home Forum Available Clinical Trials Clinical Trials Reply To: Clinical Trials

Diane Redington

The GCS Project is supporting development of and access to clinical trials for carcinosarcoma. We believe that this is where the cures are going to be found. I just returned from Birmingham, Alabama after meeting with Dr. Birrer and his team.The team is comprised of Dr. Warner Huh who is head of the Division of Obstetrics and Gynecology at UAB; Dr. Rebecca Arend who is Assistant Professor of Gynecological Oncology and is expanding her research to include GCS; and Dr. Mansoor Saleh who is the Director of the Phase One Clinical Trials unity.

There is currently one clinical trial open for solid tumors. It is not specific to carcinosarcoma but the trial will accept GCS patients because we have solid tumors. It is called A Study Exploring the Safety and Efficacy of INCAGN01949 in Combination With Immune Therapies in Advanced or Metastatic Malignancies.

Here is what I know about the trial: It is phase 1 immunology trial. (if you do not understand the differences between Phases 1,2,3 and 4, here is a link to the Society of Gynecological Oncology website. The site includes several videos: https://www.sgo.org/patients-caregivers-survivors/clinical-trials/

This trial will test 2-3 agents including Opdivo, Yervoy and an experimental drug called OX40. The study participant may receive Opdivo and OX40, Yervoy and OX40 or all 3 drugs. Very basically, OX40 is designed to ramp up our T cells. T cells are antibodies that kill off foreign invaders like cancer. If we do not have enough T cells, we cannot fight off these foreign invaders.

However, even if we have enough T cells, the cancer will find a way to block the T-cells from attacking the cancer. Opdivo and Yervoy are immunotherapies that remove these blockades and enable the T-cells to do their work. (This is very basic).

This particular trial is designed to test these 3 agents. There are other trials that test similar agents. As we become aware of them, we will post them. For more detailed information about this trial, here is a link to ClinicalTrials.gov where you can find much more information about the study, the drug company, eligibility requirements and enrollment information.

This may or may not be the right trial for you. Speak to you Oncologist to see if it is right for you.