Clinical Trials – Leads and Recommendations

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6-25-2018

Below is a list of Clinical Trials found on clinicaltrials.gov that accept patients with carcinosarcoma and are currently recruiting.  

Please visit a study’s website for more information about inclusion and exclusion criteria.

To find detailed information on a study, please go to web address for each trial. If the link does not work, go to https://www.clinicaltrials.gov/ and enter the NCT number (study number).

 

 

  1. A Study of DKN-01 as a Monotherapy or in Combination With Paclitaxel in Patients With Relapsed/ Refractory Endometrioid Endometrial or Endometrioid Ovarian Cancer (P204) (P204)
  • Study Number: NCT03395080
  • https://clinicaltrials.gov/ct2/show/study/NCT03395080
  • Locations: AL, FL, MA, MS, TN
  • Principal Investigator: Rebecca Arend, MD, University of Alabama at Birmingham
  • Paclitaxel (Taxol) –antimicrotubule agent
  • DKN-01–an inhibitor of DKK1, which modulates both the canonical and noncanonical Wnt signaling pathway 
  • Please note that the description of this study on the clinicaltrials.gov website does not include carcinosarcoma; however, the study is accepting patients with carcinosarcoma. It has also recently been expanded to include patients with epithileal ovarian cancer and carcinosarcoma.

 

2. A Study Exploring the Safety and Efficacy of INCAGN01949 in Combination With Immune Therapies in Advanced or Metastatic Malignancies. 

  • Study Number: NCT03241173
  • https://clinicaltrials.gov/ct2/show/NCT03241173
  • Locations: At UAB and 34 other sites (US, Spain, Switzerland and UK)
  • Study Director: John E. Janik, MD, Incyte Corporation
  • INCAGN01949 – an anti-OX40 agonist antibody
  • Combination therapy with Nivolumab (Opdivo), a programmed death receptor-1 (PD-1) blocking antibody
  • Combination therapy with Ipilimumab (Yervoy), blocks the CTLA-4 protein so that the T-cells stay switched on and active to attack cancer cells.  CTLs are cytotoxic T lymphocytes.

 

3. A Phase 1/2, Open-Label, Dose-Escalation, Safety Study of INCAGN01949in Subjects With Advanced or Metastatic Solid Tumors

 

  1. Trial On Trabectedin In The Treatment Of Advanced Uterine And Ovarian Carcinosarcoma (CS)_MITO 26 (MITO 26)

 

  1. Paclitaxel/Carboplatin + Galunisertib for Patients With Carcinosarcoma of the Uterus or Ovary

 

  1. A Study of Durvalumab With or Without Tremelimumab in Endometrial Cancer
  • Study Number: NCT03015129
  • https://clinicaltrials.gov/ct2/show/NCT03015129
  • Locations: Memorial Sloan Kettering in NY and NJ
  • Principal Investigator: Vicky Makker, MD, Memorial Sloan Kettering Cancer Center
  • Durvalumab – an anti-PD-L1 (programmed death ligand 1)
  • Tremelimumab – an immune checkpoint blocker (against CTLA-4)

 

  1. Vorinostat (SAHA) in Uterine Sarcoma
  • Study Number: NCT03509207
  • https://clinicaltrials.gov/ct2/show/NCT03509207
  • Location: Graz, Austria
  • Principal Investigator: Edgar Petru, Department of OB/GYN of the Medical University of Graz, Austria
  • Vorinostat (Zolinza) – an HDAC-inhibitor. The study is for patients whose tumor shows a high expression of HDAC.

 

  1. A study of Nivolumab in Selected Uterine Cancer Patients
  • Study Number: NCT03241745
  • https://clinicaltrials.gov/ct2/show/NCT03241745
  • Locations: Memorial Sloan Kettering in NY and NJ
  • Principal Investigator: Clair Freidman, MD, Memorial Sloan Kettering Cancer Center
  • Nivolumab (Opdivo) – a programmed death receptor-1 (PD-1) blocking antibody

 

  1. Mirvetuximab Soravtansine and Rucaparib Camsylate in Treating Participants With Recurrent Endometrial, Ovarian, Fallopian Tube or Primary Peritoneal Cancer
  • Recruiting
  • Study Number: NCT03552471
  • https://clinicaltrials.gov/ct2/show/NCT03552471
  • Location: Ohio State University Comprehensive Cancer Center
  • Principal Investigator: Floor Backes, MD, Ohio State University Comprehensive Cancer Center
  • Mirvetuximab Soravtansine – Antibody Drug Conjugate for patients with folate receptor alpha (FRα)-positive (targets folate receptor-α)
  • Rucaparib Camsylate (Rubraca), a PARP inhibitor
  • Patients must have confirmation of folate receptor-a (FR-alpha) positivity by immunohistochemistry (IHC)

 

  1. Short Course Vaginal Cuff Brachytherapy in Treating Patients With Stage I-II Endomentrial Cancer (SAVE)
  • Study Number: NCT03422198
  • https://clinicaltrials.gov/ct2/show/NCT03422198
  • Location: Huntsman Cancer Institute/University of Utah
  • Principal Investigator: David Gaffney, Huntsman Cancer Institute/University of Utah
  • For patients post hysterectomy and free from residual disease

 

  1. Nivolumab and Ipilimumab in Treating Patients with Rare Tumors
  • Study Number: NCT02834013
  • https://clinicaltrials.gov/ct2/show/NCT02834013?term=NCT02834013&rank=1
  • Locations: 831 study locations in the US
  • Principal Investigator: Sandip Patel, Southwest Oncology Group
  • Nivolumab (Opdivo) – a programmed death receptor-1 (PD-1) blocking antibody
  • Ipilimumab (Yervoy) – blocks the CTLA-4 protein so that the T-cells stay 

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